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Medchemexpress LLC Trimethylamine N-oxide dihydrate | 62637-93-8 | 99.86% | 111.14 | 10 MG
Supplier: Medchemexpress LLC HY1089155G
Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite derived from dietary choline and other trimethylamine-containing nutrients. It is known to induce inflammation and accelerate fibroblast-myofibroblast differentiation. This compound is commonly found in marine organisms, providing protection against adverse effects of temperature, salinity, high urea, and hydrostatic pressure.
- Increases the size and migration of fibroblasts.
- Enhances TGF-β receptor I expression.
- Promotes Smad2 phosphorylation.
- Up-regulates α-SMA and collagen I expression.
- Decreases ubiquitination of TGF-βRI and inhibits smurf2 expression.
- Can be used in animal models to induce cardiovascular and metabolic diseases.
- Stimulates cardiac hypertrophy.
- Induces cardiac hypertrophy and fibrosis in SD rats.
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