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Apexbio Technology LLC Trimipramine (maleate) 521-78-8 1g
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Supplier:  Apexbio Technology LLC C57341000

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Trimipramine (maleate) is a tricyclic antidepressant that exerts antagonistic activities at histamine H1 serotonin 5-HT2A and 1-adrenergic receptors with reported Kd values of 0 27 nM 24 nM and 24 nM respectively It also moderately interacts with muscarinic cholinergic receptors (Kd 58 nM) and dopamine D2 receptors (Kd 180 nM) Additionally trimipramine exhibits modest inhibitory effects on serotonin reuptake (Ki 149 nM for SERT) with weaker inhibition of norepinephrine (Ki 2 5 M for NET) and dopamine transporters (Ki 3 8 M for DAT) It is frequently utilized in neuropharmacological research to explore receptor-mediated neuronal signaling pathways and therapeutic mechanisms underlying depression

Catalog No. 50-000-64084


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