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Apexbio Technology LLC Triptolide 38748-32-2 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A38915.1
Triptolide (CAS 38748-32-2) is a biologically active diterpenoid originally isolated from the traditional Chinese herb Tripterygium wilfordii It exerts inhibitory effects by suppressing interleukin-2 expression in activated T cells and impeding NF- B-mediated transcriptional activation Triptolide inhibits invasion and migration of ovarian cancer cells via reducing matrix metalloproteinases MMP-7 and MMP-19 expression and enhancing E-cadherin expression Additionally it induces RNA polymerase II degradation leading to apoptosis and reduced proliferation in cancer cell lines and rheumatoid arthritis synovial fibroblasts Consequently triptolide serves as a valuable tool for immunology oncology and inflammation research
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