Tris(2-carboxyethyl)phosphine hydrochloride, 95%, 0.5M soln. in water

Description

CAS: 51805-45-9 | C9H12O6P | 247.16 g/mol

Tris(2-carboxyethyl)phosphine hydrochloride is widely used as a reducing agent to reduce disulfide bonds in proteins and trans-4,5-dihydroxy-1,2-dithiane. It is involved in the reduction of sulfoxides, sulfonyl chlorides, N-oxides and azides. It plays an important role in the tissue homogenization process for RNA isolation. It acts as a chelating agent and forms complexes with various heavy metal ions such as Zn(II), Cd(II), Pb(II), and Ni(II). Furthermore, it is useful in the labeling of cysteine residues with maleimides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tris(2-carboxyethyl)phosphine hydrochloride is widely used as a reducing agent to reduce disulfide bonds in proteins and trans-4,5-dihydroxy-1,2-dithiane. It is involved in the reduction of sulfoxides, sulfonyl chlorides, N-oxides and azides. It plays an important role in the tissue homogenization process for RNA isolation. It acts as a chelating agent and forms complexes with various heavy metal ions such as Zn(II), Cd(II), Pb(II), and Ni(II). Furthermore, it is useful in the labeling of cysteine residues with maleimides.

Solubility
Miscible with water and methanol.

Notes
Air sensitive. Store in cool place. Incompatible with strong oxidizing agents

Specifications

Chemical Identifiers

• CAS: 51805-45-9
• Molecular Formula: C9H12O6P
• Molecular Weight (g/mol): 247.16
• MDL Number: MFCD00145469
• InChI Key: PZBFGYYEXUXCOF-UHFFFAOYSA-K
• Synonym: tris 2-carboxyethyl phosphine hydrochloride, tcep hcl, tcep hydrochloride, 3,3',3-phosphinetriyltripropanoic acid hydrochloride, tcep, unii-h49aam893k, tris carboxyethyl phosphine hydrochloride, tris-2-carboxyethyl phosphine hydrochloride, tris 2-carboxyethyl phosphine hcl, 3,3',3-phosphinetriyltripropanoicacidhydrochloride
• PubChem CID: 2734570
• IUPAC Name: 3-[bis(2-carboxyethyl)phosphanyl]propanoic acid;hydrochloride
• SMILES: [O-]C(=O)CCP(CCC([O-])=O)CCC([O-])=O

• Linear Formula: (HO₂CCH₂CH₂)₃P·HCl
• Quantity: 5 mL
• UN Number: UN3265
• Solubility Information: Miscible with water and methanol.
• Formula Weight: 286.65
• Percent Purity: 95%
• Concentration or Composition (by Analyte or Components): 0.5M soln. in water
• Chemical Name or Material: Tris(2-carboxyethyl)phosphine hydrochloride

Safety and Handling

Hazard Category	H314-H335
Hazard Statement	GHS H Statement H314 Causes severe skin burns and eye damage.
Precautionary Statement	P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: III; Proper Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only