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Medchemexpress LLC Trispiro[3H-indole-3,2'-dioxane-5',5''-dioxane-2'',3'''-[3H]indole]-2,2'''-dione | 442644-28-2 | 98.2% | 394.38 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY10844250MG

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JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17 μM. It affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth.

  • Inhibits canonical Wnt signaling with an IC50 of 1.17 μM.
  • Affects the multiprotein complex of β-catenin/GSK-3β/AXIN/APC/CK1 to rapidly reduce active β-catenin.
  • Downregulates Wnt target genes.
  • Inhibits colorectal cancer cell growth.
  • Increases concentration of AXIN2 and decreases the active form of β-catenin.
  • Reduces cell growth of colon cancer cell lines.
  • Shows a concentration-dependent reduction in proliferation with a GI50 value of 7.8 μM.

Catalog No. 50-003-47380


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