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Cayman Chemical Trimebutine, Purity: ≥98%, CAS: 39133-31-8, 50 g
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Catalog No. 502991065
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An opioid receptor agonist; It binds to μ-, δ-, and κ-opioid receptors (Kis = 0.34, 0.5, and 0.58 μM, respectively, in canine myenteric plexus synaptosomes) inhibits twitch contraction and ACh release induced by low-frequency electrical stimulation in isolated guinea pig LM-MP (EC50s = 0.274 and 0.215 μM, respectively); increases twitch contraction and ACh release induced by high-frequency electrical stimulation in isolated guinea pig LM-MP at ≤1 μM, but inhibits these effects at ≥10 μM; decreases the amplitude and frequency of spontaneous contractions in isolated guinea pig colonic smooth muscle strips at 30, 100, and 300 μM; inhibits BKCa and L-type calcium currents in colonic smooth muscle cells

Catalog No. 50-299-1065 Supplier Cayman Chemical Supplier No. 3157450 G
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An opioid receptor agonist; It binds to μ-, δ-, and κ-opioid receptors (Kis = 0.34, 0.5, and 0.58 μM, respectively, in canine myenteric plexus synaptosomes) inhibits twitch contraction and ACh release induced by low-frequency electrical stimulation in isolated guinea pig LM-MP (EC50s = 0.274 and 0.215 μM, respectively); increases twitch contraction and ACh release induced by high-frequency electrical stimulation in isolated guinea pig LM-MP at ≤1 μM, but inhibits these effects at ≥10 μM; decreases the amplitude and frequency of spontaneous contractions in isolated guinea pig colonic smooth muscle strips at 30, 100, and 300 μM; inhibits BKCa and L-type calcium currents in colonic smooth muscle cells

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