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Cayman Chemical -trns-ACPD 10mg
Supplier: Cayman Chemical 2884910 MG
An agonist of mGluRs (EC50s = 15, 2, 40, 23, and 82 µM for mGluR1, -2, -3, -5, and -6, respectively, in CHO cells expressing recombinant receptors, and ~800 µM for mGluR4 in baby hamster kidney cells); increases cAMP accumulation in adult rat cerebral cortex slices (EC50 = 47.8 µM) but not in isolated rat embryonic neurons or neonatal glial cells at 1-1,000 µM; increases phosphoinositide hydrolysis in neonatal rat cerebral cortex and hippocampal slices at 10-1,000 µM; induces convulsions in neonatal rats (ED50 = 100 mg/kg), an effect that can be reversed by administration of the NMDA receptor antagonists LY233053 and LY274614
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