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Cayman Chemical TrnscrIptIon Factr p53 96W 1ea
Supplier: Cayman Chemical 6000211 EA
An inhibitor of HRV 3C protease inhibits HRV 3C protease-induced proteolysis of HRV-14 precursor polyproteins in HRV-14-infected H1HeLa cells at 2 UM inhibits replication of 49 serotypes of HRV in HRV-infected H1HeLa cells (mean EC50 0.023 UM) inhibits replication of coxsackievirus 21 coxsackievirus B3 echovirus type 11 and enterovirus 70 in virus-infected MRC-5 cells (EC50s 0.147 0.183 0.014 and 0.007 UM respectively) decreases the number of HRV-2 PFUs in and IL-8 and IL-6 secretion by HRV-2-infected BEAS-2B cells at 10 UM inhibits enterovirus 71-induced limb paralysis and decreases in survival as well as reduces intestinal lung brain stem and cardiac muscle viral loads in enterovirus-71-infected neonatal mice at 0.1 mg/kg per day
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