Cayman Chemical TrnscrIPTN Factr PrI 120uL

Supplier:  Cayman Chemical 600592120 UL

A T-type calcium channel inhibitor (IC50s 89 92 and 98 nM for Cav3.1 Cav3.2 and Cav3.3 respectively in patch-clamp assays at -80 mV) selective for these channels over Cav1.2 Cav2.1 Cav2.2 and Cav2.3 in patch-clamp assays (IC50s >30 UM for all at -90 mV) reduces the viability of spheroid A549 lung cancer cells at 100 or 200 nM decreases body weight gain and fat mass and increases lean muscle mass in mice fed a high-fat diet inhibits amphetamine- or MK-801-induced locomotor activity in rats at 3 mg/kg decreases the mean time spent in active wake and REM sleep and increases the mean time spent in delta sleep in wild-type but not Cacna1g-/- and Cacna1i-/- double knockout mice when administered one hour before the inactive phase at 10 mg/kg

Catalog No. 50-289-4248