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Cayman Chemical TroglItazon 100mg
Supplier: Cayman Chemical 71750100 MG
A selective agonist of PPARγ (EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay); selective for PPARγ over PPARα and PPARδ, at which it is inactive at ≤10 μM; exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively, at 500 mg/kg twice per day; induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells at 10 μM and increases apoptosis in these cells at ≥30 μM
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