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Enzo Life Sciences Troglitazone (25mg). CAS: 97322-87-7
Supplier: Enzo Life Sciences BMLGR2100025
Antidiabetic thiazolidinedione. Potent and selective PPARγ ligand. Binds to the PPARγ ligand-binding domain and recruits ligand-specific transcriptional coactivators at 1µM. In skeletal muscle and adipocyte cell cultures, the EC50 of troglitazone is about 10µM. Displaces [125I]SB-236636 with an IC50=7.9µM. Stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. Induces apoptosis in human vascular smooth muscle cells and inhibits the growth of a variety of human cancer cells including lung, bladder and myeloid leukemia cells. Displays an anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Inhibits cell growth of hematopoietic cell lines. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (>25mg/ml), 100% ethanol (>25mg/ml, warm) or dimethyl formamide. Long Term Storage: Ambient.
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