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Medchemexpress LLC TRV-120027 TFA | 1234510-46-3 | 99.6% | 1040.10 | 5 MG
Supplier: Medchemexpress LLC HYP2141A5MG
TRV-120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) that engages β-arrestins while blocking G-protein signaling. It induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling and promotes the formation of a macromolecular complex. It inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility, with potential for acute decompensated heart failure (ADHF) treatment. For research use only.
- Engages β-arrestins while blocking G-protein signaling
- Induces acute catecholamine secretion through TRPC3 coupling
- Promotes formation of a macromolecular complex composed of AT1R-β-arrestin-1-TRPC3-PLCγ at the plasma membrane
- Inhibits angiotensin II-mediated vasoconstriction
- Increases cardiomyocyte contractility
- Potential for acute decompensated heart failure (ADHF) treatment
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