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Biogenex Laboratories TTF1 : SP141 : 6mL
Supplier: Biogenex Laboratories AN8875M
Thyroid Transcription Factor-1 (TTF-1) or thyroid-specific enhancer-binding protein (T/EBP), with a molecular weight of 40 kD is a NKx2 family member protein, it is homeodomain transcription factor specifically regulating the gene expression of lung- and thyroid tissues . It is a very selective marker for adenocarcinomas of lung and thyroid origin. Nuclear localization of this protein is seen in the epithelial cells of thyroid gland and lung (2). The anti-TTF-1 antibody is a useful tool for differentiating pulmonary adenocarcinoma from metastatic breast carcinoma and mesothelioma.
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