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Apexbio Technology LLC Tubastatin A 1252003-15-8 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A41015.1

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Tubastatin A (CAS 1252003-15-8) is a selective inhibitor of histone deacetylase 6 (HDAC6) an enzyme mediating acetylation states crucial for regulating both histone and non-histone proteins Tubastatin A inhibits HDAC6 with an IC50 of approximately 15 nM and shows minimal activity against class I HDAC isoforms demonstrating greater than 200-fold selectivity In vitro Tubastatin A induces hyperacetylation of -tubulin reduces neuronal cell death inhibits inflammatory cytokines (IL-6 TNF) production in human THP-1 macrophages and decreases NO secretion from mouse Raw 264 7 cells In animal models it exhibits anti-inflammatory and anti-tumor effects Tubastatin A is utilized in research exploring cancer biology inflammation and neuroprotection

Catalog No. 50-000-61941


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