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LifeSensors Tandem Ubiquitin Binding Entities (TUBE2) His6 1mg
Supplier: LifeSensors UM02021000
Tandem Ubiquitin Binding Entities (TUBEs) have been developed for the isolation and identification of ubiquitinated proteins. TUBEs display up to a 1000-fold increase in affinity for poly-ubiquitin moieties over the single ubiquitin binding associated domain (UBA). TUBEs display a protective effect on polyubiquitinated proteins, allowing for detection at relatively low abundance. These properties effectively “capture” proteins in their polyubiquitinated state. The ubiquitination state of cellular proteins can be directly related to various diseases including neurodegeneration, inflammation and cancer. However, ubiquitinated proteins are intrinsically unstable, which can preclude the characterization of the ubiquitinylation state. TUBEs fill this void in ubiquitin research, allowing the identification of ubiquitin-modified proteins that cannot be detected with current technologies. TUBEs are used to isolate, enrich, and identify ubiquitinated proteins from cells, tissues, and organs.
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