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Research Products International Corp Tunicamycin, 10 MG
Supplier: Research Products International Corp T225000.01
Tunicamycin is a nucleoside antibiotic that inhibits the biosynthesis of N-linked glycoproteins. It inhibits the formation of N-glycosidic linkages during the early steps of protein glycosylation. Also, it interferes with the transfer of N-acetylglucosamine-1-phosphate to dolichol phosphate, a crucial step in the synthesis of lipid-linked oligosaccharides. As a result, the glycosylation process in the endoplasmic reticulum is disrupted.
Widely used as a tool in cell biology and biochemistry to study protein glycosylation. It helps researchers investigate the effects of impaired glycosylation on cellular processes. This antibiotic induces endoplasmic reticulum (ER) stress by disrupting protein folding and glycosylation in the ER. This property is utilized in studies focused on understanding ER stress responses and unfolded protein response pathways.
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