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Apexbio Technology LLC TW-37 877877-35-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A42345.1
TW-37 (CAS 877877-35-5) is a small-molecule inhibitor targeting BCL-2 family proteins It binds specifically to the BH3 domain-binding groove of anti-apoptotic members such as BCL-2 (Ki 290 nmol/L) BCL-XL (Ki 1 110 nmol/L) and MCL-1 (Ki 260 nmol/L) By disrupting interactions between pro-apoptotic (e g Bid Bim Bad) and anti-apoptotic proteins TW-37 promotes apoptosis in cancer cells TW-37 demonstrates antiproliferative effects against various cancer lines mediating S-phase cell cycle arrest and altering expression of multiple cell cycle regulators It serves as a valuable tool compound for apoptosis-related cancer research
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