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Medchemexpress LLC TX1-85-1 | 1603845-32-4 | 99.7% | 580.68 | 1 MG
Supplier: Medchemexpress LLC 1MGHY100848
TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. It acts as the first selective Her3 ligand, forming a covalent bond with Cys721 in the ATP-binding site of Her3. This compound induces partial degradation of Her3 protein and attenuates Her3-dependent signaling, showing anti-proliferation effects in various cell lines.
- Irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM
- First selective Her3 ligand forming a covalent bond with Cys721
- Induces partial degradation of Her3 protein
- Attenuates Her3-dependent signaling
- Demonstrates anti-proliferation EC50s of 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively
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