Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 50 MG

Supplier:  Medchemexpress LLC HY1666850MG

Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It blocks CD40L-induced translocation of NF-κB to the nucleus and reduces the activation of the IL-12 p40 gene. In vivo therapy with A1 leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells and attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice.

• Target: IL-12 production inhibitor
• Dose-dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM
• Significantly weaker inhibitor of TK than other tyrphostins (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase)
• Useful for differentiating TK-mediated effects of tyrphostins from other non-specific effects

Catalog No. 50-003-94254