Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY16668

Tyrphostin A1 (AG9) is a compound that inhibits CD40L-stimulated IL-12 production and antigen-induced generation of Th1 cells. It blocks CD40L-induced translocation of NF-κB to the nucleus, reducing IL-12 p40 gene activation. In vivo, it decreases the generation of myelin basic protein (MBP) specific encephalitogenic T cells and attenuates experimental allergic encephalomyelitis (EAE).

• Inhibits CD40L-stimulated IL-12 production in macrophage cultures
• Inhibits antigen-induced generation of Th1 cells
• Blocks CD40L-induced translocation of NF-κB to the nucleus
• Reduces activation of the IL-12 p40 gene
• Decreases generation of myelin basic protein (MBP) specific encephalitogenic T cells
• Attenuates experimental allergic encephalomyelitis (EAE)
• Differentiates TK-mediated effects from non-specific effects due to weak TK inhibition (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase)

Catalog No. 50-003-95182