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Enzo Life Sciences Tyrphostin AG 1478 (5mg). CAS: 153436-53-4
Supplier: Enzo Life Sciences ALX270036M005
EGFR inhibitor. Potent and selective inhibitor of EGFR (IC50 = 3nM). Reduces EGF-stimulated DNA synthesis in Rat-1 fibroblasts by ~75% at 0.25μM. Blocks EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction in A431 cells. Also inhibits H2O2-induced stimulation of amphiregulin expression in rat gastric epithelium (RGM 1) cells. Alternative name: 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline. Formula: C16H14ClN3O2. MW: 315.8. Purity: ≥98% (HPLC). Appearance: White to light yellow solid. Solubility: Soluble in DMSO (10mg/ml). Long Term Storage: -20°C. Handling: Protect from light. Packaged under inert gas.
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