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Medchemexpress LLC Tyrphostin AG1296 | 146535-11-7 | 99.69% | 266.29 | 5 MG
Supplier: Medchemexpress LLC 5MGHY13894
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR) with an IC50 of 0.8 μM. It inhibits the signaling of human PDGF α- and β-receptors, the related stem cell factor receptor (c-Kit), and FLT3.
- Potent and selective inhibitor of PDGFR with an IC50 of 0.8 μM.
- Inhibits signaling of human PDGF α- and β-receptors.
- Inhibits the related stem cell factor receptor (c-Kit).
- Potent inhibitor of FLT3 in the micromolar range.
- Suppresses viability of PLX4032-resistant melanoma cells.
- Induces apoptosis of A375R cells.
- Inhibits PDGFR phosphorylation.
- Inhibits migration of A375R cells.
- Suppresses tumor growth in mice models.
- Inhibits atherosclerotic plaque progression and enhances plaque stability.
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