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Medchemexpress LLC Tyrphostin AG1296 | 146535-11-7 | 99.7% | 266.29 | 25 MG
Supplier: Medchemexpress LLC 25MGHY13894
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. It inhibits signaling of human PDGF α- and β-receptors, as well as the related stem cell factor receptor (c-Kit). This compound is also a potent inhibitor of FLT3, with an IC50 in the micromolar range.
- Potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR)
- Inhibits signaling of human PDGF α- and β-receptors
- Inhibits signaling of the related stem cell factor receptor (c-Kit)
- Potent inhibitor of FLT3
- Suppresses viability of PLX4032-resistant melanoma cells
- Induces apoptosis of A375R cells
- Inhibits PDGFR phosphorylation
- Suppresses A375R tumor growth in vivo
- Inhibits atherosclerotic plaque progression
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