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Cayman Chemical U-99194maleate 10mg
Supplier: Cayman Chemical 3585410 MG
A dopamine D3 receptor antagonist (Ki = 160 nM for the human receptor); selective for dopamine D3 receptors over the α1-AR (Ki = 8,913 nM for the rat receptor), M1 mAChR, 5-HT1A, and dopamine D4 receptor (Kis = 2,090, 4,230, and >10,000 nM for the human receptors); reverses (+)-7-OH-DPAT- or PD 128907-induced hypothermia in rats (ID50s = 19.1 and 12.9 mg/kg, respectively); increases non-social exploration, social investigation, and the latency to attack in a mouse model of isolation-induced aggressiveness at 40 mg/kg
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