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Cayman Chemical U-ContoxInacetate 10mg
SDP

Supplier:  Cayman Chemical 4245510 MG

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A conotoxin and an inhibitor of Nav1.4 receptors; inhibits Nav1.4 in HEK293 cells (IC50 = 2.3 nM for the rat channel); inhibits rat Nav1.2 channels in HEK293 cells at 500 nM and is an antagonist of a7 nAChRs and a4ß2 and a3ß2 subunit-containing nAChRs in Xenopus oocytes expressing the human receptors (IC50s = 22, 2.9, and 0.45 µM, respectively); reduces global nerve action potential in isolated mouse sciatic nerves in a concentration-dependent manner; inhibits contraction in isolated mouse hemidiaphragm muscles (IC50 = 46 nM)

Catalog No. 50-294-3923


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