Apexbio Technology LLC U0126-EtOH 1173097-76-1 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A13375.1

U0126-EtOH is a selective inhibitor of the MEK1 and MEK2 kinases exhibiting IC50 values of approximately 70 nM and 60 nM respectively U0126-EtOH binds specifically to MAP kinase kinases MEK1 and MEK2 in a noncompetitive manner toward ERK substrates and ATP effectively inhibiting downstream phosphorylation and activation of ERK signaling This compound was initially identified as an inhibitor of AP-1 transcriptional activity In cellular assays utilizing HT22 mouse neuronal cells and cultured primary cortical neurons U0126-EtOH reduces cellular injury caused by oxidative glutamate toxicity and hypoxia/reoxygenation by preventing ERK1/2 phosphorylation U0126-EtOH can serve as a tool compound for studying MEK/ERK signaling pathways in vitro particularly in models involving neuronal oxidative stress-induced injury

Catalog No. 50-000-63070