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Eurofins Discoverx InCELL Hunter U2OS Bcl2-Bim Protein Binding Cell Line, 2 vials. (96-0008C3)
Supplier: Eurofins Discoverx 960008C3
The InCELL Hunter U2OS Bcl2-Bim Protein Binding Cell Line provides an easy-to-use cell based assay to study small molecule drug candidates that disrupt protein binding. This kit assesses compound-based disruption of Bcl2-Bim binding via detection of Bim levels. This product uses EFC technology. The cell line included overexpresses Bcl2 target in an untagged form and Bim binding partner fused to ProLabel. When a compound engages the Bcl2 target protein, partner binding is disrupted and the destabilized Bim is degraded, leading to a loss of EFC signal upon addition of EA containing detection reagent. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
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