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Eurofins Discoverx PathHunter U2OS c-Ret-GFRα3 Functional Assay, 2 vials. (93-1143C3)
Supplier: Eurofins Discoverx 931143C3
The PathHunter U2OS c-Ret-GFRα3 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated c-Ret and GFRα3 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged c-Ret and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, GFRα3. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the cynomolgus version of the protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
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