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Eurofins Discoverx PathHunter U2OS CFTR-ΔF508 MEM-EA Pharmacotrafficking Assay, 2 vials. (93-0987C3)
Supplier: Eurofins Discoverx 930987C3
The PathHunter U2OS CFTR-ΔF508 MEM-EA Pharmacotrafficking Assay is a stable, engineered cell line for use in studying pharmacochaperones targeting CFTR. This cell line enables assessment of chaperone-based stabilization of CFTR-ΔF508 via detection of rescued membrane trafficking. The included cell line overexpresses ProLink-tagged mutant CFTR-ΔF508, which is misfolded and retained in the ER. The cell line also expresses membrane-localized EA. When a pharmacochaperone stabilizes the mutant CFTR, it is trafficked to the membrane, producing EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
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