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Eurofins Discoverx PathHunter U2OS KCNH2(G601S) MEM-EA Pharmacotrafficking Assay, 2 vials. (93-1064C3)
Supplier: Eurofins Discoverx 931064C3
The PathHunter U2OS KCNH2(G601S) MEM-EA Pharmacotrafficking Assay is a stable, engineered cell line for use in studying pharmacochaperones targeting KCNH2. This cell line enables assessment of chaperone-based stabilization of KCNH2(G601S) via detection of rescued membrane trafficking. The included cell line overexpresses ProLink-tagged mutant KCNH2(G601S), which is misfolded and retained in the ER. The cell line also expresses membrane-localized EA. When a pharmacochaperone stabilizes the mutant KCNH2, it is trafficked to the membrane, producing EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
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