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Eurofins Discoverx PathHunter U2OS MC4R(T162I) ENDO-EA Pharmacotrafficking Assay, 2 vials. (93-1004C3)

Supplier:  Eurofins Discoverx 931004C3

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The PathHunter U2OS MC4R(T162I) Pharmacotrafficking Assay is a stable, engineered cell line for use in studying pharmacochaperones targeting MC4R. This cell line enables assessment of chaperone-based stabilization of MC4R(T162I) via detection of rescued membrane-endosome trafficking. The included cell line overexpresses ProLink-tagged mutant MC4R(T162I), which is misfolded and retained in the ER. The cell line also expresses endosome-localized EA. When a pharmacochaperone stabilizes the mutant MC4R, it is trafficked to the membrane and then internalized to the endosome, producing EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.

Catalog No. 50-200-1817


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