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AdipoGen UBS109 (5 x 1 mg)
SDP

Supplier:  AdipoGen AGCR137045001

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Chemical. CAS: 1258513-40-4. Formula: C18H17N3O. MW: 291.4. Most water soluble synthetic monocarbonyl analog of curcumin (MAC) for in vitro and in vivo application. Potently inhibits NF-kappaB and its nuclear translocation by suppressing IKK-alpha and IKK-beta, consequently leading to apoptosis. Potent DNA hypomethylating agent. Inhibits HSP90 and NF-kappaB leading to downregulation of DNA methyltransferase-1 (DNMT-1) expression. Cytotoxic against several cancers in vitro and in vivo. Shows excellent activity against xenografts of head and neck squamous cell carcinoma, pancreatic cancer, colon cancer and breast cancer. Antiangiogenic agent. Induces the downregulation of HIF-1alpha, HSP90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts.

Catalog No. 50-205-4074


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