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Medchemexpress LLC UC-112 | 383392-66-3 | 98.9% | 100 MG
Supplier: Medchemexpress LLC HY12842100MG
UC-112 is a survivin and XIAP modulator exhibiting anticancer activity. It functions by selectively downregulating and degrading survivin through the ubiquitin-mediated proteasomal pathway. This compound also effectively reduces XIAP levels in in vivo tumor models, leading to the activation of caspase-3/7 and caspase-9, and ultimately inducing apoptosis in cancer cells. It is suitable for research on melanoma, prostate cancer, and other cancer-related studies.
- Selectively downregulates and degrades survivin
- Reduces XIAP levels in in vivo tumor models
- Activates caspase-3/7 and caspase-9
- Induces cancer cell apoptosis
- Inhibits proliferation of A375, M14, PC-3, and DU145 cancer cells
- Alters cell cycle distribution in A375 melanoma cells
- Inhibits human melanoma tumor growth in nude mice
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