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Medchemexpress LLC UCL 1684 dibromide | 199934-16-2 | 98.1% | 654.44 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY108579

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UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. It is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of INa, causing atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness. In vitro studies show it produces direct atrial-selective inhibition of sodium channel current (INa) and shifts SS inactivation of cardiac sodium channels. It also induces PRR, decreases Vmax, increases DTE, and extends the shortest S1-S1 interval.

  • First nanomolar, non-peptidic SK channel blocker.
  • Effective in preventing atrial fibrillation by atrial-selective inhibition of INa.
  • Induces atrial-selective prolongation of ERP.
  • Increases wenckebach cycle length in vivo.

Catalog No. 50-003-47250


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