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Cayman Chemical UCL-TRO-1938 10mg
SDP

Supplier:  Cayman Chemical 3911810 MG

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An allosteric PI3Kα activator; It binds to PI3Kα in an SPR assay (Kd = 36 µM) and induces PI3Kα activation in a cell-free assay at 25 and 50 µM; increases PtdIns-(3,4,5)-P3 and phosphorylated Akt levels in MEFs (EC50s = 5 and 2-4 µM, respectively); increases tissue survival and decreases infarct size in perfused rat hearts; reduces infarct size in a mouse model of LAD coronary artery occlusion-induced ischemia-reperfusion injury at 10 mg/kg; increases the number of motor neurons and innervation of neuromuscular junctions in a rat model of sciatic nerve crush injury

Catalog No. 50-291-8669


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