Cayman Chemical UFP101 trifluoroacetate salt

Supplier:  Cayman Chemical 36833500 UG

A synthetic peptide and nociceptin receptor antagonist (Ki = 0.06 nM in CHO cells expressing the human receptor); selective for the nociceptin receptor over the κ-opioid receptor (Ki = 204 nM in CHO cells expressing the rat receptor); inhibits GTPγS release from the nociceptin receptor expressed in CHO cell membranes (EC50 = 1.86 nM); increases the latency to tail withdrawal in the tail-flick test in mice at 10 nmol/animal, i.c.v.; increases survival in a mouse model of sepsis induced by cecal ligation and puncture at 0.003, 0.03, and 0.3 mg/kg

Catalog No. 50-290-9889