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STEMCELL Technologies SBI-0206965, Size: 5 mg
Supplier: STEMCELL Technologies 1000269
SBI-0206965 is an inhibitor of the autophagy initiator kinases ULK1 and ULK2 (IC₅₀ = 108 nM and 711 nM, respectively; Egan et al.). SBI-0206965 is also a potent inhibitor of AMP-activated protein kinase (AMPK), a positive regulator of autophagy (Dite et al.). CANCER RESEARCH· Synergizes with mTOR inhibition to induce apoptosis and cell death in tumor cells (Egan et al.).· Suppresses autophagy induced by mTOR inhibition (Egan et al.).· Suppresses prosurvival autophagic responses in tumor cells through AMPK and ULK1 inhibition (Dite et al.).
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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