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Invitrogen™ ULK1 Recombinant Human Protein

ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. Recombinant human ULK1 (1-649) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Manufacturer:  Invitrogen™ PV6430

Encompass

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Catalog No. PV6430


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Description

Description

The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
Specifications

Specifications

Liquid
Baculovirus
Kinase Assay
Biochemical binding/kinetic
96.1 kDa
ATG1, UNC51, Unc51.1, FLJ38455
Yes
Recombinant
Human
Serine/Threonine Kinase
ULK1
10μg
aa 1-649
GST Tag
Safety and Handling

Safety and Handling

SDS
Documents
Product Certifications
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