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Eurofins Discoverx ULK2, active, 250 µg. (14-772M)
Supplier: Eurofins Discoverx 14772M
N-terminal GST and C-terminal 6xHis-tagged recombinant, human, ULK2 amino acids 1–306. Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. For detailed product information, visit www.discoverx.com/proteins.
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