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AdipoGen Umbellulone

Supplier: AdipoGen AGCN20085M100

Chemical. CAS 546-78-1. Formula C10H14O. MW 150.2. Isolated from Umbellularia californica Nutt. Offensive principle of the so-called "headache tree". Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP calcitonin gene-related peptide after TRPA1 activation which leads to activation of trigeminovascular pathways and CGRP-mediated neurogenic vasodilatation relevant to produce headache/migraine.
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