Medchemexpress LLC Umeclidinium bromide | 869113-09-7 | MFCD18782614 | 508.49 | 1 G

Supplier:  Medchemexpress LLC HYW0044151G

Umeclidinium bromide is a novel mAChR antagonist, demonstrating high affinity for cloned human M1-M5 mAChRs with Ki values ranging from 0.05 to 0.16 nM. It is a potent agent that exhibits slow functional reversibility at cloned human M3 mAChRs and endogenous mAChRs in isolated human bronchus. This compound is suitable for research in various disease areas including neurological, eye or ear disease, cancer, inflammation or immune system disease, neurodegenerative disease, and Parkinson's disease.

• Novel mAChR antagonist
• High affinity for human M1-M5 mAChRs (Ki 0.05-0.16 nM)
• Inhibits human ether-a-go-go-related gene channel tail current with an IC50 of 9.4 μM
• Demonstrates slow functional reversibility at human M3 mAChRs
• Applicable for research in neurological, ocular, oncological, inflammatory, and neurodegenerative conditions

Catalog No. 50-004-48776