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Apexbio Technology LLC UNC0638 1255580-76-7 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A19145.1

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UNC0638 is a selective inhibitor of histone methyltransferases G9a and GLP enzymes responsible for mono- and dimethylation of histone H3 lysine-9 (H3K9) It inhibits G9a and GLP activity with IC50 values of 15 nM and 19 nM respectively UNC0638 reduces cellular H3K9 dimethylation levels demonstrated in MDA-MB-231 cells with an IC50 of 81 9 nM at 48 hours It has been utilized in models to study epigenetic regulation including neuroendocrine tumor xenografts and hair cell damage induced by aminoglycosides addressing roles of H3K9 methylation in disease pathogenesis and therapeutic responses

Catalog No. 50-000-63051


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