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Medchemexpress LLC UNC10217938A | 1347749-97-6 | 99.75% | 456.54 | 100 MG
Supplier: Medchemexpress LLC HY136151100MG
UNC10217938A is a 3-deazapteridine analog with strong oligonucleotide enhancing effects. It enhances oligonucleotide effects by modulating their intracellular trafficking and release from endosomes, and also enhances the effects of antisense and siRNA oligonucleotides.
- Enhances luciferase induction in HelaLuc705 cells
- Enhances effects of receptor-targeted oligonucleotide conjugates, uncharged morpholino oligonucleotides, and negatively charged oligonucleotides
- Causes partial release of oligonucleotide from late endosomes to the cytosol followed by nuclear accumulation
- Systemic treatment produces distinct increases in EGFP fluorescence in liver, kidney, and heart in EGFP654 mice
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