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Cayman Chemical UNC8153trIfluoROCTAte sal 10mg
Supplier: Cayman Chemical 3893210 MG
A degrader of NSD2; induces degradation of NSD2 (DC50 = 350 nM); selective for NSD2 over NSD1 and NSD3 at 20 µM; induces NSD2 degradation and reduces H3K35me2 in MM.1S cells at 10 µM; reduces the proliferation of MM.1S cells expressing NSD2 containing an activating NSD2E1099K mutation, but not MDA-MB-231, U2OS, or HEK293 cells expressing wild-type NSD2, at 20 µM; decreases attachment of MM.1S cells in a migration assay at 20 µM
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