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Medchemexpress LLC UNC9994 hydrochloride | 2108826-33-9 | 99.5% | 457.84 | 10 MG
Supplier: Medchemexpress LLC HY111385100MG
UNC9994 hydrochloride is a functionally selective, β-arrestin-biased dopamine D2 receptor (D2R) agonist. It selectively activates β-arrestin recruitment and signaling, demonstrating antipsychotic-like activity. It also acts as an antagonist of Gi-regulated cAMP production and a partial agonist for D2R/β-arrestin-2 interactions.
- Selectively activates β-arrestin recruitment and signaling.
- Antagonist of Gi-regulated cAMP production.
- Partial agonist for D2R/β-arrestin-2 interactions.
- Shows antipsychotic-like activity.
- Induces D2-mediated β-arrestin-2 translocation with EC50s of 6.1 nM and 448 nM.
- Acts as an antagonist at 5HT2A and 5HT2B receptors.
- Acts as an agonist at 5HT2C and 5HT1A receptors.
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