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Cayman Chemical Upadacitinib 10mg
SDP

Supplier:  Cayman Chemical 2970610 MG

Encompass_Preferred

A JAK1 inhibitor (IC50 = 47 nM); selective for JAK1 over JAK3 and Tyk2 (IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 µM, but does inhibit JAK2, ROCK1, and ROCK2 (IC50s = 120, 920 and 430 nM, respectively); decreases cytokine-induced STAT phosphorylation in a variety of human cells (IC50s = 1.6-649 nM); reduces M. tuberculosis-induced paw swelling and bone erosion in a rat model of arthritis at 1, 3, and 10 mg/kg twice per day for 17 days

Catalog No. 50-299-2365


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