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Medchemexpress LLC Upadacitinib | 1310726-60-3 | 100.0% | 380.37 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY19569100MG

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Upadacitinib (ABT-494) is a potent, orally active, and selective Janus kinase 1 (JAK1) inhibitor with an IC50 of 43 nM. It demonstrates approximately 74-fold selectivity for JAK1 over JAK2 (IC50=200 nM) and 58-fold selectivity over JAK3 in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be utilized for research related to several autoimmune disorders.

  • Potent, orally active, and selective JAK1 inhibitor
  • Displays approximately 74-fold selectivity for JAK1 over JAK2 (IC50=200 nM)
  • Displays approximately 58-fold selectivity for JAK1 over JAK3
  • May offer an improved benefit-risk profile in patients with RA due to enhanced selectivity for JAK-1 over JAK-2 and JAK-3
  • Demonstrates efficacy in rat arthritis models

Catalog No. 50-004-01145


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