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Medchemexpress LLC Urea, N-[1-[(2-amino-4-pyridinyl)methyl]-1H-indol-4-yl]-N'-(5-bromo-2-methoxyphenyl)- | 900573-88-8 | 99.0% | 466.33 | 25 MG
SDP

Catalog No. 5000395119
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JI-101 is an orally available multi-kinase inhibitor of VEGFR2, PDGFRβ, and EphB4 with potent anti-cancer activity. It is stable in preclinical and human liver microsomes and is rapidly absorbed after oral administration, demonstrating extensive tissue distribution with preferred uptake into lung tissue.

  • Orally available multi-kinase inhibitor targeting VEGFR2, PDGFRβ, and EphB4
  • Demonstrates potent anti-cancer activity
  • Stable across various preclinical and human liver microsomes
  • Rapidly absorbed after oral administration, reaching Cmax within 2 hours
  • Exhibits extensive tissue distribution, with preferred uptake into lung tissue
  • Highly soluble in DMSO (≥ 100 mg/mL)
  • Excreted through bile with mono- and di-hydroxy metabolites

Catalog No. 50-003-95119 Supplier Medchemexpress LLC Supplier No. 25MGHY16265
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JI-101 is an orally available multi-kinase inhibitor of VEGFR2, PDGFRβ, and EphB4 with potent anti-cancer activity. It is stable in preclinical and human liver microsomes and is rapidly absorbed after oral administration, demonstrating extensive tissue distribution with preferred uptake into lung tissue.

  • Orally available multi-kinase inhibitor targeting VEGFR2, PDGFRβ, and EphB4
  • Demonstrates potent anti-cancer activity
  • Stable across various preclinical and human liver microsomes
  • Rapidly absorbed after oral administration, reaching Cmax within 2 hours
  • Exhibits extensive tissue distribution, with preferred uptake into lung tissue
  • Highly soluble in DMSO (≥ 100 mg/mL)
  • Excreted through bile with mono- and di-hydroxy metabolites

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