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Medchemexpress LLC Urea, N-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxo-3-pyrrolidinyl]-N'-phenyl- | 2253947-47-4 | 99.7% | 250 MG
SDP

Catalog No. 5000342808
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This compound is a selective, orally active agonist of formyl peptide receptor 2 (FPR2), exhibiting strong agonistic activity in both human and mouse models. It shows promise in attenuating cardiac remodeling after myocardial infarction, suggesting potential for preventing heart failure. Its mechanism involves inhibiting neutrophil chemotaxis and stimulating macrophage phagocytosis, crucial for resolving inflammation. Suitable for in vitro and in vivo research, it demonstrates good oral bioavailability in animal models.

  • Selective agonist of formyl peptide receptor 2 (FPR2).
  • Highly selective for FPR2 (human EC50 0.41 nM, mouse EC50 3.4 nM).
  • Inhibits neutrophil chemotaxis; promotes macrophage phagocytosis.
  • Attenuates cardiac remodeling after myocardial infarction.
  • Orally active with 24% bioavailability in mice.
  • Purity: 99.74%.
  • Molecular formula: C18H17F2N3O3.
  • Molecular weight: 361.34.

Catalog No. 50-003-42808 Supplier Medchemexpress LLC Supplier No. 250MGHY131180
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This compound is a selective, orally active agonist of formyl peptide receptor 2 (FPR2), exhibiting strong agonistic activity in both human and mouse models. It shows promise in attenuating cardiac remodeling after myocardial infarction, suggesting potential for preventing heart failure. Its mechanism involves inhibiting neutrophil chemotaxis and stimulating macrophage phagocytosis, crucial for resolving inflammation. Suitable for in vitro and in vivo research, it demonstrates good oral bioavailability in animal models.

  • Selective agonist of formyl peptide receptor 2 (FPR2).
  • Highly selective for FPR2 (human EC50 0.41 nM, mouse EC50 3.4 nM).
  • Inhibits neutrophil chemotaxis; promotes macrophage phagocytosis.
  • Attenuates cardiac remodeling after myocardial infarction.
  • Orally active with 24% bioavailability in mice.
  • Purity: 99.74%.
  • Molecular formula: C18H17F2N3O3.
  • Molecular weight: 361.34.

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