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Medchemexpress LLC Urea, N-[4-[4-(4-morpholinyl)-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl]-N'-4-pyridinyl | 1197160-28-3 | 98.0% | 488.54 | 100 MG
SDP

Catalog No. 5000343841
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PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, showing anti-tumor activity in vivo. It is for research use only and not sold to patients.

  • Potent and orally active dual PI3K/mTOR inhibitor.
  • Exhibits activity over E545K and H1047R.
  • Inhibits cell proliferation with IC50s of 22 nM for MDA-MB-361 cells and 29 nM for PC-3 cells.
  • Good oral bioavailability (98% in nude mouse, 46% in rat, 38% in monkey, and 61% in dog).
  • High half-life (>60 min).
  • Appearance: Solid, off-white to yellow.
  • Shows anti-tumor activity in vivo.
  • Well tolerated in nude mice bearing MDA-361 human breast cancer tumors.
  • Exhibits pronounced tumor growth arrest when dosed above 10 mg/kg in nude mice.

Catalog No. 50-003-43841 Supplier Medchemexpress LLC Supplier No. HY1108010MG
May include imposed supplier surcharges.
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PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, showing anti-tumor activity in vivo. It is for research use only and not sold to patients.

  • Potent and orally active dual PI3K/mTOR inhibitor.
  • Exhibits activity over E545K and H1047R.
  • Inhibits cell proliferation with IC50s of 22 nM for MDA-MB-361 cells and 29 nM for PC-3 cells.
  • Good oral bioavailability (98% in nude mouse, 46% in rat, 38% in monkey, and 61% in dog).
  • High half-life (>60 min).
  • Appearance: Solid, off-white to yellow.
  • Shows anti-tumor activity in vivo.
  • Well tolerated in nude mice bearing MDA-361 human breast cancer tumors.
  • Exhibits pronounced tumor growth arrest when dosed above 10 mg/kg in nude mice.

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